About Mithra

    Specialists in women’s health

    Transforming options for women through innovation

    Mithra is dedicated to providing innovation and choice in women’s health, with a particular focus on contraception and menopause. Mithra’s goal is to develop new and improved products that meet women’s needs for better safety and convenience. Its three lead development candidates – a fifth generation oral contraceptive Estelle®, the first complete oral treatment for perimenopause PeriNesta™ and next-generation hormone therapy Donesta® – are built on Mithra’s unique native estrogen platform, E4 (Estetrol). Mithra also develops and manufactures complex therapeutics and offers partners a complete spectrum of research, development and specialist manufacturing at its Mithra CDMO.

    Our mission is to help transform women’s health by offering new choices through innovation with a particular focus on contraception and menopause

    Today, Mithra has two complementary platforms powered by a unique CDMO facility: its innovative E4-based pipeline and its portfolio of complex therapeutics

    Estetrol (E4) based projects

    E4 is a naturel oestrogen produced by the human foetus during pregnancy. Mithra believes E4 has potential benefits over current estrogens in key areas including oral contraception and hormone therapy (HT).

    Mithra is focused on the development of three late-stage E4-based products : Estelle®, a 5th generation oral contraceptive, PeriNesta™, the first complete oral treatment for perimenopause and Donesta®, a next-generation hormone therapy for VMS in menopause.


    Complex therapeutics

    Mithra also has extensive expertise in the development of complex and innovative products, using medical polymer technology.

    Mithra is developing a contraceptive vaginal ring (Myring™), a biodegradable subcutaneous implant (Zoreline®) for hormone dependant cancer. In 2016, the company also launched Tibelia®, a therapeutic solution composed of tibolone for menopause.


    Mithra CDMO

    A fully integrated ecosystem for state-of-the-art research, development & manufacturing.

    Mithra CDMO is a unique facility specialized in polymeric forms, sterile injectables and hormonal tablets.


    The name Mithra refers to the Persian god worshipped for 4,000 years and means contract, partner, ally. In Greco-Roman mythology, Mithra slew the bull and restored the reign of fertility and abundance.

    The bull is itself the symbol of the city of Liège. Mithra and the values that the name conveys are embedded in the company’s DNA.