Complex therapeutics

Innovation to improve drug delivery using polymer technology

Mithra has extensive expertise in the development of complex and innovative products using medical polymer technology. The company is leveraging this expertise to target improved, long-lasting delivery of trusted, established approaches to contraception, menopause and hormone-dependent cancers. The Company’s current research and development pipeline includes three complex therapeutics : Myring™ for contraception, Zoreline® for hormone-dependent cancers and Tibelia® for menopause.

What is long-acting technology?

Polymer technology allows prolonged drug delivery based on the use of polymer matrices. These enable a drug’s active pharmaceutical ingredient (API) to be distributed at a predetermined rate over a period of time (from 1 month to 5 years), maintaining controlled drug delivery with minimum side effects.

It is used for various drug delivery strategies : intra-uterine devices, vaginal rings or implants. Little to no action is required by the patient, which improves compliance and therefore yields better results.

Only a few companies in the world master the development of sustained-release platforms. Mithra is one of them.

R&D projects

Myring™

Contraception

Myring is a contraceptive vaginal ring releasing a combination of hormones, made of ethylene-vinyl-acetate (EVA) copolymers.

Myring is developed to be a generic of Nuvaring® vaginal ring.

Tibelia®

Menopause & Osteoporosis

Tibelia® is a therapeutical solution composed of Tibolone, a synthetic steroid used for hormone therapy (HT) and developed by Mithra.

Tibelia is developed to be a generic of Livial®.

Zoreline®

Hormone-dependent cancers

Zoreline® is a biodegradable subcutaneous implant for prostate and breast cancer and benign gynecological indications (endometriosis, uterine fibroids).

Mithra is currently developing a one-month implant (3.6 mg goserelin) and a 3-month implant (10.8 mg goserelin). Zoreline® is being developed to be a generic of Zoladex®.

Projects pipeline

Formulation
Clinical Development
Registration
Myring™ - Contraception
Tibelia® - Menopause
Zoreline® - Implant 3 month - Hormone-dependent cancers
Zoreline® - Implant 1 month - Hormone-dependent cancers

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